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pentobarbital will decrease the extent or outcome of tramadol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Lowered AUC of tramadol along with the active metabolite (O-desmethyltramadol) when coadministered with sturdy CYP3A4 and CYP2B6 inducersElderly patients may perhaps respond to barbiturates with marked pleasure,

This could also transpire in unborn infants When the mother employs Nembutal in the third trimester of pregnancy. Talk with the health practitioner.pentobarbital will lower the level or result of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Coadministration of fentanyl with CYP3A4